Publications

  • 2017

  • Structural and Biophysical Analysis of the Soluble DHH/DHHA1-Type Phosphodiesterase TM1595 from Thermotoga maritima
    Drexler DJ, Müller M, Rojas-Cordova CA,Bandera AM, Witte G
    Structure. 2017 Oct 24. pii: S0969-2126(17)30329-5.

    Link

  • RNA structure refinement using NMR solvent accessibility data.
    Hartlmüller C, Günther JC, Wolter AC, Wöhnert J, Sattler M, Madl T.
    Sci Rep. 2017 Jul 14;7(1):5393. doi: 10.1038/s41598-017-05821-z.

    Link

  • Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation.
    Heuer A, Gerovac M, Schmidt C, Trowitzsch S, Preis A, Kötter P, Berninghausen O, Becker T, Beckmann R, Tampé R.
    Nat Struct Mol Biol. 2017 May;24(5):453-460. doi: 10.1038/nsmb.3396. Epub 2017 Apr 3.

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  • Site-specific recruitment of epigenetic factors with a modular CRISPR/Cas system.
    Anton T, Bultmann S.
    Nucleus. 2017 Feb 23:1-8. doi: 10.1080/19491034.2017.1292194.

    Link

  • 2016

  • The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.
    Schmidt C, Kowalinski E, Shanmuganathan V, Defenouillère Q, Braunger K, Heuer A, Pech M, Namane A, Berninghausen O, Fromont-Racine M, Jacquier A, Conti E, Becker T, Beckmann R.
    Science. 2016 Dec 16;354(6318):1431-1433

    Link

  • Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons.
    Huter P, Müller C, Beckert B, Arenz S, Berninghausen O, Beckmann R, Wilson DN.
    Nature. 2016 Dec 1. doi: 10.1038/nature20821.

    Link

  • A Simple and Sensitive High-Content Assay for the Characterization of Antiproliferative Therapeutic Antibodies.
    Stengl A, Hörl D, Leonhardt H and Helma J
    J Biomol Screen, 2016 Dec 1. [Epub ahead of print]

    Link

  • Recognition of the 3' splice site RNA by the U2AF heterodimer involves a dynamic population shift.
    Voith von Voithenberg L, Sánchez-Rico C, Kang HS, Madl T, Zanier K, Barth A, Warner LR, Sattler M, Lamb DC.
    Proc Natl Acad Sci U S A. 2016 Oct 31. pii: 201605873.

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  • Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing.
    Jagtap PK, Garg D, Kapp TG, Will CL, Demmer O, Luhrmann R, Kessler H, Sattler M.
    J Med Chem. 2016 Oct 18.

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  • Determination of local chromatin composition by CasID.
    Schmidtmann E, Anton T, Rombaut P, Herzog F, Leonhardt H.
    Nucleus. 2016 Sep 27:1-9.

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  • Impact of Heterogeneity and Lattice Bond Strength on DNA Triangle Crystal Growth.
    Stahl E, Praetorius F, de Oliveira Mann CC, Hopfner KP, Dietz H.
    ACS Nano. 2016 Sep 7.

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  • Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome.
    Kornprobst M, Turk M, Kellner N, Cheng J, Flemming D, Koš-Braun I, Koš M, Thoms M, Berninghausen O, Beckmann R, Hurt E.
    Cell. 2016 Jul 14;166(2):380-93. doi: 10.1016/j.cell.2016.06.014.

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  • Architecture and RNA binding of the human negative elongation factor.
    Vos SM, Pöllmann D, Caizzi L, Hofmann KB, Rombaut P, Zimniak T, Herzog F, Cramer P.
    Elife. 2016 Jun 10;5. pii: e14981. doi: 10.7554/eLife.14981.

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  • Structural and biochemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1.
    de Oliveira Mann CC, Kiefersauer R, Witte G, Hopfner KP.
    Sci Rep. 2016 Jun 8;6:27498. doi: 10.1038/srep27498.

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  • The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis.
    Arenz S, Abdelshahid M, Sohmen D, Payoe R, Starosta AL, Berninghausen O, Hauryliuk V, Beckmann R, Wilson DN.
    Nucleic Acids Res. 2016 May 25. pii: gkw470.

    Link

  • Transcription initiation complex structures elucidate DNA opening.
    Plaschka C, Hantsche M, Dienemann C, Burzinski C, Plitzko J, Cramer P.
    Nature. 2016 May 11;533(7603):353-8. doi: 10.1038/nature17990.

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  • Visualization of Genomic Loci in Living Cells with a Fluorescent CRISPR/Cas9 System.
    Anton T, Leonhardt H, Markaki Y.
    Methods Mol Biol. 2016;1411:407-17. doi: 10.1007/978-1-4939-3530-7_25.

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  • Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin.
    Friese A, Faesen AC, Huis In 't Veld PJ, Fischböck J, Prumbaum D, Petrovic A, Raunser S, Herzog F, Musacchio A.
    Nat Commun. 2016 Apr 20;7:11407. doi: 10.1038/ncomms11407.

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  • Translation regulation via nascent polypeptide-mediated ribosome stalling.
    Wilson DN, Arenz S, Beckmann R.
    Curr Opin Struct Biol. 2016 Apr;37:123-33. doi: 10.1016/j.sbi.2016.01.008. Epub 2016 Feb 7.

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  • Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50.
    Seifert FU, Lammens K, Stoehr G, Kessler B, Hopfner KP.
    EMBO J. 2016 Apr 1;35(7):759-72. doi: 10.15252/embj.201592934. Epub 2016 Feb 19.

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  • Nucleotide-dependent conformational changes of the AAA+ ATPase p97 revisited.
    Schuller JM, Beck F, Lossl P, Heck AJ, and Förster F.
    FEBS letters. 2016 Feb 5. doi: 10.1002/1873-3468.12091.

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  • 2015

  • Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome.
    Schmidt C, Becker T, Heuer A, Braunger K, Shanmuganathan V, Pech M, Berninghausen O, Wilson DN, Beckmann R.
    Nucleic Acids Res. 2015 Dec 28. pii: gkv1517. [Epub ahead of print]

    Link

  • Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling.
    Barrio-Garcia C, Thoms M, Flemming D, Kater L, Berninghausen O, Baßler J, Beckmann R, Hurt E.
    Nat Struct Mol Biol. 2016 Jan;23(1):37-44. doi: 10.1038/nsmb.3132. Epub 2015 Nov 30.

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  • ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.
    Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, García-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.
    eLife. 2015 Nov 26;4. pii: e10859. doi: 10.7554/eLife.10859.http://elifesciences.org/content/4/e10859

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  • Structural insights into the cooperative remodeling of membranes by amphiphysin/BIN1.
    Adam J, Basnet N, Mizuno N.
    Scientific Reports. 2015 Oct 21;5:15452. doi: 10.1038/srep15452.

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  • Structure of Ctk3, a subunit of the RNA polymerase II CTD kinase complex, reveals a noncanonical CTD-interacting domain fold.
    Mühlbacher W, Mayer A, Sun M, Remmert M, Cheung AC, Niesser J, Söding J, Cramer P
    Proteins. 2015 Oct;83(10):1849-58. doi: 10.1002/prot.24869. Epub 2015 Aug 24.

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  • A modular open platform for systematic functional studies under physiological conditions
    Mulholland CB, Smets M, Schmidtmann E, Leidescher S, Markaki Y, Hofweber M, Qin W, Manzo M, Kremmer E, Thanisch K, Bauer C, Rombaut P, Herzog F, Leonhardt H, Bultmann S
    Nucleic Acids Res. 2015 Sep 30;43(17):e112. doi: 10.1093/nar/gkv550. Epub 2015 May 24.

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  • Structure of the native Sec61 protein-conducting channel.
    Pfeffer S, Burbaum L, Unverdorben P, Pech M, Chen Y, Zimmermann R, Beckmann R, Förster F.
    Nat Commun. 2015 Sep 28;6:8403. doi: 10.1038/ncomms9403.

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  • Structural disorder and its role in proteasomal degradation.
    Aufderheide A, Unverdorben P, Baumeister W, Förster F.
    FEBS Lett. 2015 Sep 14. doi: 10.1016/j.febslet.2015.07.034.

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  • Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1.
    Butryn A, Schuller JM, Stoehr G, Runge-Wollmann P, Förster F, Auble DT, Hopfner K-P
    Elife. 2015 Aug 10;4. doi: 10.7554/eLife.07432.

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  • RNA degradation paths in a 12-subunit nuclear exosome complex.
    Makino DL, Schuch B, Stegmann E, Baumgartner M, Basquin C, Conti E
    Nature. 2015 Aug 6;524(7563):54-8. doi: 10.1038/nature14865. Epub 2015 Jul 29.

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  • Structure of the catalytic domain of Mre11 from Chaetomium thermophilum.
    Seifert FU, Lammens K, Hopfner KP
    Acta Crystallogr F Struct Biol Commun. 2015 Jun;71(Pt 6):752-7. doi: 10.1107/S2053230X15007566. Epub 2015 May 22.

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  • Structural analysis of the di-adenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.
    Müller M, Deimling T, Hopfner KP, Witte G.
    Biochem J. 2015 May 27. [Epub ahead of print]

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  • The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex.
    Seefeldt AC, Nguyen F, Antunes S, Pérébaskine N, Graf M, Arenz S, Inampudi KK, Douat C, Guichard G, Wilson DN, Innis CA.
    Nat Struct Mol Biol. 2015 May 18. doi: 10.1038/nsmb.3034. [Epub ahead of print]

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  • Cryo-EM structure of the tetracycline resistance protein TetM in complex with a translating ribosome at 3.9-A resolution.
    Arenz S, Nguyen F, Beckmann R, Wilson DN
    Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5401-6. doi: 10.1073/pnas.1501775112. Epub 2015 Apr 13.

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  • The conformational plasticity of eukaryotic RNA-dependent ATPases.
    Ozgur S, Buchwald G, Falk S, Chakrabarti S, Prabu JR, Conti E.
    FEBS J. 2015 Mar;282(5):850-63. doi: 10.1111/febs.13198. Epub 2015 Feb 4.

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  • Structural Basis for Dodecameric Assembly States and Conformational Plasticity of the Full-Length AAA+ ATPases Rvb1·Rvb2.
    Lakomek K, Stoehr G, Tosi A, Schmailzl M, Hopfner KP
    Structure. 2015 Mar 3. doi: 10.1016/j.str.2014.12.015. Epub 2015 Feb 5.

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  • Architecture of the RNA polymerase II-Mediator core initiation complex.
    Plaschka C, Larivière L, Wenzeck L, Seizl 2, Hemann M, Tegunov D, Petrotchenko EV, Borchers CH, Baumeister W, Herzog F, Villa E, Cramer P.
    Nature. 2015 Feb 19;518(7539):376-80. doi: 10.1038/nature14229. Epub 2015 Feb 4.

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  • bbcontacts: prediction of β-strand pairing from direct coupling patterns.
    Andreani J, Söding J.
    Bioinformatics. 2015 Jan 23. pii: btv041.

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  • Proteasome assembly from 15S precursors involves major conformational changes and recycling of the Pba1-Pba2 chaperone.
    Kock M, Nunes MM, Hemann M, Kube S, Jürgen Dohmen R, Herzog F, Ramos PC, Wendler P
    Nat Commun. 2015 Jan 22. doi: 10.1038/ncomms7123.

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  • 2014

  • Structure of the Rad50 DNA double-strand break repair protein in complex with DNA.
    Rojowska A, Lammens K, Seifert FU, Direnberger C, Feldmann H, Hopfner KP.
    EMBO J. 2014 Dec 1;33(23):2847-59. doi: 10.15252/embj.201488889. Epub 2014 Oct 27.

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  • A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.
    Baßler J, Paternoga H, Holdermann I, Thoms M, Granneman S, Barrio-Garcia C, Nyarko A, Stier G, Clark SA, Schraivogel D, Kallas M, Beckmann R, Tollervey D, Barbar E, Sinning I, Hurt E.
    J Cell Biol. 2014 Nov 24. doi: 10.1083/jcb.201408111.

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  • c-di-AMP recognition by Styphylococcus aureus PstA.
    Müller M, Hopfner KP and Witte G
    FEBS Lett. 2015 Jan 2;589(1):45-51. doi: 10.1016/j.febslet.2014.11.022. Epub 2014 Nov 28.

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  • Molecular architecture of the HerA-NurA DNA double-strand break resection complex.
    Byrne RT, Schuller JM, Unverdorben P, Förster F, Hopfner KP.
    FEBS Lett. 2014 Nov 11. doi: 10.1016/j.febslet.2014.10.035.

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  • Architecture and ssDNA interaction of the Timeless-Tipin-RPA complex.
    Witosch J, Wolf E, Mizuno N.
    Nucleic Acids Res. 2014 Nov 10;42(20):12912-27. doi: 10.1093/nar/gku960. Epub 2014 Oct 27.

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  • Drug Sensing by the Ribosome Induces Translational Arrest via Active Site Perturbation.
    Arenz S, Meydan S, Starosta AL, Berninghausen O, Beckmann R, Vázquez-Laslop N, Wilson DN.
    Mol Cell. 2014 Nov 6. doi: 10.1016/j.molcel.2014.09.014.

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  • CCMpred--fast and precise prediction of protein residue-residue contacts from correlated mutations.
    Seemayer S, Gruber M1, Söding J.
    Bioinformatics. 2014 Nov 1;30(21):3128-30. doi: 10.1093/bioinformatics/btu500. Epub 2014 Jul 26.

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  • Structure of the Rad50 DNA double-strand break repair protein in complex with DNA.
    Rojowska A, Lammens K, Seifert F, Direnberger C, Feldmann H and Hopfner KP.
    EMBO J. 2014 October 27. DOI: 10.15252/embj.201488889

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  • The molecular architecture of the TRAMP complex reveals the organization and interplay of its two catalytic activities.
    Falk S, Weir JR, Hentschel J, Reichelt P, Bonneau F, Conti E.
    Mol Cell. 2014 Sep 18;55(6):856-67. doi: 10.1016/j.molcel.2014.07.020. Epub 2014 Aug 28.

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  • Structural model of a CRISPR RNA-silencing complex reveals the RNA-target cleavage activity in Cmr4.
    Benda C, Ebert J, Scheltema RA, Schiller HB, Baumgärtner M, Bonneau F, Mann M, Conti E.
    Mol Cell. 2014 Oct 2;56(1):43-54. doi: 10.1016/j.molcel.2014.09.002.

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  • Transcriptome maps of mRNP biogenesis factors define pre-mRNA recognition.
    Baejen C, Torkler P, Gressel S, Essig K, Söding J, Cramer P.
    Mol Cell. 2014 Sep 4. doi: 10.1016/j.molcel.2014.08.005.

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  • Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6.
    Chakrabarti S, Bonneau F, Schüssler S, Eppinger E, Conti E.
    Nucleic Acids Res. 2014 Aug;42(14):9447-60. doi: 10.1093/nar/gku578. Epub 2014 Jul 10.

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  • Crystal and solution structure of the human RIG-I SF2 domain.
    Deimling T, Cui S, Lammens K, Hopfner KP and Witte G.
    Acta Cryst. 2014 August. F70, 1027-1031

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  • Emerging mechanistic insights into AAA complexes regulating proteasomal degradation.
    Förster F, Schuller JM, Unverdorben P, Aufderheide A.
    Biomolecules. 2014 Aug 6. doi: 10.3390/biom4030774.

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  • Structural studies of DNA end detection and resection in homologous recombination.
    Schiller CB1 Seifert FU, Linke-Winnebeck C, Hopfner KP.
    Cold Spring Harbour Perspectives in Biology. 2014 Jul 31 doi: 10.1101/cshperspect.a017962.

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  • The structure of the Pan2-Pan3 core complex reveals cross-talk between deadenylase and pseudokinase.
    Schäfer IB, Rode M, Bonneau F, Schüssler S, Conti E.
    Nat Struct Mol Biol. 2014 Jul 21

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  • Conserved architecture of the core RNA polymerase II initiation complex.
    Mühlbacher W, Sainsbury S, Hemann M, Hantsche M, Neyer S, Herzog F, Cramer P.
    Nat Commun. 2014 Jul 10

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  • A structural model of the active ribosome-bound membrane protein insertase YidC.
    Wickles S, Singharoy A, Andreani J, Seemayer S, Bischoff L, Berninghausen O, Soeding J, Schulten K, van der Sluis EO, Beckmann R.
    Elife. 2014 Jul 10. e03035. doi: 10.7554/eLife.03035.

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  • Cryoelectron Microscopic Structures of Eukaryotic Translation Termination Complexes Containing eRF1-eRF3 or eRF1-ABCE1.
    Preis A, Heuer A, Barrio-Garcia C, Hauser A, Eyler DE, Berninghausen O, Green R, Becker T, Beckmann R.
    Cell Rep. 2014 Jul 4

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  • Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes.
    Leitner A, Joachimiak LA, Unverdorben P, Walzthoeni T, Frydman J, Förster F, Aebersold R.
    Proc Natl Acad Sci U S A. 2014 Jul 1. doi: 10.1073/pnas.1320298111.

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  • Structure of the VipA/B Type VI Secretion Complex Suggests a Contraction-State-Specific Recycling Mechanism.
    Kube S
    , Kapitein N, Zimniak T, Herzog F, Mogk A, Wendler P.
    Cell Rep. 2014 Jun 17

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  • Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression.
    Mathys H, Basquin J, Ozgur S, Czarnocki-Cieciura M, Bonneau F, Aartse A, Dziembowski A, Nowotny M, Conti E, Filipowicz W.
    Mol Cell. 2014 Jun 5.

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  • Transient electrostatic interactions dominate the conformational equilibrium sampled by multidomain splicing factor U2AF65: a combined NMR and SAXS study.
    Huang JR, Warner LR, Sanchez C, Gabel F, Madl T, Mackereth CD, Sattler M, Blackledge M.
    J Am Chem Soc. 2014 May 14;136(19):7068-76. doi: 10.1021/ja502030n. Epub 2014 Apr 29.

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  • Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1.
    Wang I, Hennig J, Jagtap PK, Sonntag M, Valcárcel J, Sattler M.
    Nucleic Acids Res. 2014; Epub 2014 Mar 25.

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  • Finding the right fit: chiseling structures out of cryo-electron microscopy maps.
    Villa E, Lasker K
    Curr Opin Struct Biol. 2014 Apr;25:118-25. doi: 10.1016/j.sbi.2014.04.001. Epub 2014 May 9..

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  • In Vivo Ligands of MDA5 and RIG-I in Measles Virus-Infected Cells.
    Runge S, Sparrer KM, Lässig C, Hembach K, Baum A, García-Sastre A, Söding J, Conzelmann KK, Hopfner KP.
    PLoS Pthog. 2014 Apr 17; doi: 10.1371/journal.ppat.1004081.

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  • Visualization of specific DNA sequences in living mouse embryonic stem cells with a programmable fluorescent CRISPR/Cas system.
    Anton T, Bultmann S, Leonhardt H, and Markaki Y.
    Nucleus 2014 Mar 10; doi.org/10.4161/nucl.28488

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  • Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome.
    Unverdorben P, Beck F, Sledz P, Schweitzer A, Pfeifer G, Plitzko JM, Baumeister W, and Förster F.
    PNAS 2014 Feb 25. doi:10.1073/pnas.1403409111

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  • Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion.
    Gogala M, Becker T, Beatrix B, Armache JP, Barrio-Garcia C, Berninghausen O, Beckmann R.
    Nature. 2014 Feb 6. doi: 10.1038/nature12950.

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  • The inverse BAR-domain protein IBARa drives membrane remodelling to control osmoregulation, phagocytosis and cytokinesis
    Linkner J, Witte G, Zhao H, Junemann A, Nordholz B, Runge-Wollmann P, Lappalainen P, Faix J
    J Cell Sci. 2014 Jan 24. [Epub ahead of print]

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  • Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon.
    Pfeffer S, Dudek J, Gogala M, Schorr S, Linxweiler J, Lang S, Becker T, Beckmann R, Zimmermann R, Förster F.
    Nat Commun. 2014 January 10. doi: 10.1038/ncomms4072.

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  • Optimized ratiometric calcium sensors for functional in vivo imaging of neurons and T lymphocytes.
    Thestrup T, Litzlbauer J, Bartholomäus I, Mues M, Russo L, Dana H, Kovalchuk Y, Liang Y, Kalamakis G, Laukat Y, Becker S, Witte G, Geiger A, Allen T, Rome LC, Chen TW, Kim DS, Garaschuk O, Griesinger C, Griesbeck O.
    Nat Methods. 2014 Jan 5. doi: 10.1038/nmeth.2773. [Epub ahead of print]

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  • 2013

  • Three-dimensional architecture of actin filaments in Listeria monocytogenes comet tails.
    Jasnin M, Asano S, Gouin E, Hegerl R, Plitzko JM, Villa E, Cossart P, Baumeister W.
    Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20521-6. doi: 10.1073/pnas.1320155110. Epub 2013 Dec 4.

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  • Crystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domain.
    Buchwald G, Schüssler S, Basquin C, Le Hir H, Conti E.
    Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):E4611-8. doi: 10.1073/pnas.1314684110. Epub 2013 Nov 11.

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  • Structural model for the covalent adhesion of the Streptococcus pyogenes pilus through a thioester bond.
    Linke-Winnebeck C, Paterson NG, Young PG, Middleditch MJ, Greenwood DR, Witte G, Baker EN.
    J Biol Chem. 2013 Nov 12.

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  • Transcriptome Surveillance by Selective Termination of Noncoding RNA Synthesis.
    Schulz D, Schwalb B, Kiesel A, Baejen C, Torkler P, Gagneur J, Soeding J, Cramer P.
    Cell. 2013 Nov 6. doi: 10.1016/j.cell.2013.10.024.

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  • Structure and RNA-binding properties of the Not1-Not2-Not5 module of the yeast Ccr4-Not complex.
    Bhaskar V, Roudko V, Basquin J, Sharma K, Urlaub H, Séraphin B, Conti E.
    Nat Struct Mol Biol. 2013 Nov;20(11):1281-8. doi: 10.1038/nsmb.2686. Epub 2013 Oct 13.

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  • Structure determination of an 11-subunit exosome in complex with RNA by molecular replacement.
    Makino DL, Conti E.
    Acta Crystallogr D Biol Crystallogr. 2013 Nov;69(Pt 11):2226-35. doi: 10.1107/S0907444913011438. Epub 2013 Oct 12.

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  • Architecture of the Lsm1-7-Pat1 complex: a conserved assembly in eukaryotic mRNA turnover.
    Sharif H, Conti E.
    Cell Rep. 2013 Oct 31 doi: 10.1016/j.celrep.2013.10.004.

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  • Structural features of Argonaute-GW182 protein interactions.
    Pfaff J, Hennig J, Herzog F, Aebersold R, Sattler M, Niessing D, and Meister G.
    PNAS 2013 Oct 1.

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  • Opening windows into the cell: focused-ion-beam milling for cryo-electron tomography.
    Villa E, Schaffer M, Plitzko JM, Baumeister W.
    Curr Opin Struct Biol. 2013 Oct;23(5):771-7. doi: 10.1016/j.sbi.2013.08.006. Epub 2013 Sep 30.

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  • Efficient detection of hydrogen bonds in dynamic regions of RNA by sensitivity-optimized NMR pulse sequences.
    Dallmann A, Simon B, Duszczyk MM, Kooshapur H, Pardi A, Bermel W, Sattler M.
    Angew Chem Int Ed Engl. 2013 Sep 27, doi: 10.1002/anie.201304391.

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  • Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex.
    Tosi A, Haas C, Herzog F, Gilmozzi A, Berninghausen O, Ungewickell C, Gerhold CB, Lakomek K, Aebersold R, Beckmann R, Hopfner KP.
    Cell. 2013 Sep 12 doi: 10.1016/j.cell.2013.08.016.

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  • Unveiling the Long-Held Secrets of the 26S Proteasome.
    Förster F, Unverdorben P, Sledź P, Baumeister W.
    Structure. 2013 Sep 3. doi: 10.1016/j.str.2013.08.010.

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  • Structural analysis of the yeast Dhh1-Pat1 complex reveals how Dhh1 engages Pat1, Edc3 and RNA in mutually exclusive interactions.
    Sharif H, Ozgur S, Sharma K, Basquin C, Urlaub H, Conti E.
    Nucleic Acids Res. 2013 Sep doi: 10.1093/nar/gkt600. Epub 2013 Jul 12

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  • Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins.
    von Moeller H, Lerner R, Ricciardi A, Basquin C, Marzluff WF, Conti E.
    Nucleic Acids Res. 2013 Sep;41(16):7960-71. doi: 10.1093/nar/gkt558. Epub 2013 Jun 26.

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  • The yeast ski complex: crystal structure and RNA channeling to the exosome complex.
    Halbach F, Reichelt P, Rode M, Conti E.
    Cell. 2013 Aug 15;154(4):814-26. doi: 10.1016/j.cell.2013.07.017.

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  • MuB is an AAA+ ATPase that forms helical filaments to control target selection for DNA transposition.
    Mizuno N, Dramićanin M, Mizuuchi M, Adam J, Wang Y, Han YW, Yang W, Steven AC, Mizuuchi K, Ramón-Maiques S.
    Proc Natl Acad Sci U S A. 2013 Jul 2; doi: 10.1073/pnas.1309499110. Epub 2013 Jun 17.

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  • cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.
    Ablasser A, Goldeck M, Cavlar T, Deimling T, Witte G, Rohl I, Hopfner KP, Ludwig J, Hornung V
    Nature. 2013 Jun 20;498(7454):380-4. doi: 10.1038/nature12306. Epub 2013 May 30

    Link

  • High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation.
    Müller R, Gräwert MA, Kern T, Madl T, Peschek J, Sattler M, Groll M, Buchner J.
    PNAS. 2013 Jun 18. doi: 10.1073/pnas.1300547110

    Link

  • Fast and accurate reference-free alignment of subtomograms.
    Chen Y, Pfeffer S, Hrabe T, Schuller JM, Förster F.
    J Struct Biol. 2013 Jun. doi: 10.1016/j.jsb.2013.03.002.

    Link

  • Dynamics in multi-domain protein recognition of RNA.
    Mackereth CD, Sattler M.
    Curr Opin Struct Biol. 2012 Jun. doi: 10.1016/j.sbi.2012.03.013. Epub 2012 Apr 18.

    Link

  • Structural mechanism of cytosolic DNA sensing by cGAS.
    Civril F, Deimling T, de Oliveira Mann CC, Ablasser A, Moldt M, Witte G, Hornung V, Hopfner KP
    Nature. 2013 May 30. doi: 10.1038/nature12305

    Link

  • Structures of the human and Drosophila 80S ribosome.
    Anger AM, Armache JP, Berninghausen O, Habeck M, Subklewe M, Wilson DN, Beckmann R.
    Nature. 2013 May 2;497(7447):80-5. doi: 10.1038/nature12104.

    Link

  • Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex.
    Makino DL, Baumgärtner M, Conti E.
    Nature. 2013 Mar 7;495(7439):70-5. doi: 10.1038/nature11870. Epub 2013 Feb 3.

    Link

  • Combining NMR and small angle X-ray and neutron scattering in the structural analysis of a ternary protein-RNA complex.
    Henning J, Wang I, Sonntag M, Gabel F, Sattler M.
    J Biomol NMR 2013 March 03

    Link

  • Translational repression of thymidylate synthase by targeting its mRNA.
    Garg D, Beribisky AV, Ponterini G, Ligabue A, Marverti G, Martello A, Costi MP, Sattler M, Wade RC.
    Nucleic Acids Res 2013 February 18.

    Link

  • Structural and functional analysis of the DEAF-1 and BS69 MYND domains.
    Kateb F, Perrin H, Tripsianes K, Zou P, Spadaccini R, Bottomley M, Franzmann TM, Buchner J, Ansieau S, Sattler M.
    PLoS One. 2013. doi: 10.1371/journal.pone.0054715. Epub 2013 Jan 25.

    Link

  • Paramyxovirus V Proteins Disrupt the Fold of the RNA Sensor MDA5 to Inhibit Antiviral Signaling.
    Motz C, Schuhmann KM, Kirchhofer A, Moldt M, Witte G, Conzelmann KK, Hopfner KP
    Science 2013 January 17. doi: 10.1126/science.1230949
    (Science Express)

    Link

  • Structure and function of the initially transcribing RNA polymerase II-TFIIB complex.
    Sainsbury S, Niesser J, Cramer P.
    Nature 2013 January 17. doi: 10.1038/nature.11715

    Link

  • Structural basis of transcription elongation.
    Martinez-Rucobo FW, Cramer P.
    Biochim Biophys Acta 2013 January. doi: 10.1016/j.bbagrm.2012.09.002.

    Link

  • 2012

  • Structure of the Mediator head module.
    Larivière L, Plaschka C, Seizl M, Wenzeck L, Kurth F, Cramer P.
    Nature 2012 December 20. doi: 10.1038/nature11670

    Link

  • Structural characterization of a eukaryotic chaperone—the ribosome-associated complex
    Leidig C,Bange G, Kopp J, Amlacher S, Aravind A, Wickles S, Witte G, Hurt E, Beckmann R, Sinning I
    NSMB 2012 December 2. doi:10.1038/nsmb.2447

    Link

  • Discriminative modelling of context-specific amino acid substitution probabilities.
    Angermüller C, Biegert A, Söding J.
    Bioinformatics 2012 December 1. doi: 10.1093/bioinformatics/bts622

    Link

  • Structure of Actin-related protein 8 and its contribution to nucleosome binding.
    Gerhold CB, Winkler DD, Lakomek K, Seifert FU, Fenn S, Kessler B, Witte G, Luger K, Hopfner KP.
    Nucleic Acids Res. 2012 Nov;40(21):11036-46. doi: 10.1093/nar/gks842. Epub 2012 Sep 12.

    Link

  • Architecture of the nuclease module of the yeast Ccr4-not complex: the Not1-Caf1-Ccr4 interaction.
    Basquin J1, Roudko VV, Rode M, Basquin C, Séraphin B, Conti E.
    Mol Cell. 2012 Oct 26;48(2):207-18. doi: 10.1016/j.molcel.2012.08.014. Epub 2012 Sep 6.

    Link

  • Near-atomic resolution structural model of the yeast 26S proteasome.
    Beck F*, Unverdorben P*, Bohn S, Schweitzer A, Pfeifer G, Sakata E, Nickell S, Plitzko JM, Villa E, Baumeister W, Förster F. *contributed equally
    PNAS 2012 September 11. doi: 10.1073/pnas.1213333109

    Link

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